This gums up the works.

Hollywood celebrities using popular weight loss drug Ozempic to shred those unwanted pounds are now facing an unexpected new side effect dubbed “Ozempic mouth,” according to a report.

Users of the hottest prescription drug in Tinseltown, including Sharon Osbourne, Whoopie Goldberg, and Rebel Wilson, are showing signs of the distinctive side effect linked to rapid facial weight loss from a higher dose of the GLP-1 medication, a New York-based cosmetic dermatologist told the DailyMail.com

Veteran TV personality Sharon Osbourne, who lost 42 pounds on Ozempic, is exhibiting signs of "Ozempic mouth," a New York dermatologist suspects.
Veteran TV personality Sharon Osbourne, who lost 42 pounds on Ozempic, is exhibiting signs of “Ozempic mouth,” a New York dermatologist suspects.Getty Images
“Many users of Ozempic who I know report noticeable volume loss in the face, which can result in the formation of fine lines, wrinkles, sagging skin, and jowls around the mouth,” Dr. Michele Green said.

“This volume loss can also worsen the appearance of existing fine lines, wrinkles, and skin laxity contributing to a more aged smile and overall look.”

Dr. Michele Green told the DailyMail that "Ozempic mouth" is liked to rapid facial weight loss.
Dr. Michele Green told the DailyMail that “Ozempic mouth” is liked to rapid facial weight loss.mbruxelle – stock.adobe.com
Green said the condition is marked by pronounced folds at the corners of the mouth, noticeable wrinkles on the lips, and sagging skin along the lip contours and chin area.

But those alarmed by their appearance are now turning to cosmetic treatments – such as dermal fillers – to restore lost volume around the mouth area.

Green believes Whoopie Goldberg is also experiencing side effects.
Green believes Whoopie Goldberg is also experiencing side effects.Getty Images
Green told the outlet that fillers, an injectable substance used to improve the appearance of facial lines, wrinkles and folds, can “restore volume to the face, smooth the appearance of fine lines and wrinkles, and plump the skin to create a more youthful-looking appearance.”

Though she recommends Thermage, a non-invasive skin tightening treatment that uses radiofrequency energy to rejuvenate the skin.

Rebel Wilson
Rebel WilsonGetty Images for BFC
“As the body’s collagen levels increase, the skin becomes firmer and tighter,” she told the outlet, explaining that it takes four to six months to see results that will last for less than two years.

“Patients on Ozempic should ideally undergo a Thermage procedure early in treatment or before treatment begins to prevent the development of loose, sagging skin on the face.”

The latest fallout from the buzzed-about pound-shedding drug is related to the dreaded symptom known as “Ozempic face,” where users are exhibiting sunken features and drooping skin.

Other reported symptoms of the weight-slimming drug include what’s being called “Ozempic feet,” a troubling side effect characterized by pronounced skin laxity on the tops of users’ feet.